Tchem GPR35 G-protein coupled receptor 35

Protein Summary

Description

Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.

Uniprot Accession IDs

• Q9HC97
• J3KR30
• O43495
• Q17R58
• Q4VBN5
• Q4ZFV2
• Q6FHI8
• Q86UH4

Gene Name

• GPR35

Ensembl ID

• ENST00000319838
• ENSP00000322731
• ENSG00000178623
• ENST00000403859
• ENSP00000385140
• ENST00000407714
• ENSP00000384263
• ENST00000430267
• ENSP00000411788
• ENST00000438013
• ENSP00000415890

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.79
tissue sample	0.68
tissue	0.59
gene perturbation	0.56
transcription factor	0.55

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / G-protein Coupled Receptor 35

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.02   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 210   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.02   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2