EML4
Echinoderm microtubule-associated protein-like 4
Protein Summary
May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]
- ENST00000318522
- ENSP00000320663
- ENSG00000143924
- ENST00000402711
- ENSP00000385059
- C2orf2
- EMAPL4
- C2orf2
- ELP120
- EMAP-4
- EMAPL4
- ROPP120
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.85 | ||
microRNA | 0.81 | ||
transcription factor perturbation | 0.8 | ||
transcription factor | 0.79 | ||
cell type or tissue | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 350.8 (req: < 5)
Gene RIFs: 84 (req: <= 3)
Antibodies: 122 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 350.8 (req: >= 5)
Gene RIFs: 84 (req: > 3)
Antibodies: 122 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0