Tbio TMBIM4 Protein lifeguard 4

Protein Summary

Description

Anti-apoptotic protein which can inhibit apoptosis induced by intrinsic and extrinsic apoptotic stimuli. Can modulate both capacitative Ca2+ entry and inositol 1,4,5-trisphosphate (IP3)-mediated Ca2+ release.

Uniprot Accession IDs

• Q9HC24
• Q542Z6
• Q9UHY5
• Q9Y3C2

Gene Name

• TMBIM4

Ensembl ID

• ENST00000358230
• ENSP00000350965
• ENSG00000155957

Symbol

• GAAP
• LFG4
• S1R
• GAAP
• LFG4
• ZPRO
• CGI-119

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
transcription factor binding site profile	0.87
transcription factor perturbation	0.84
gene perturbation	0.76
histone modification site profile	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.41   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.41   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0