SGK2
Serine/threonine-protein kinase Sgk2
Protein Summary
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na(+) channels: SCNN1A/ENAC, K(+) channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
- ENST00000341458
- ENSP00000340608
- ENSG00000101049
- ENST00000373092
- ENSP00000362184
- ENST00000373100
- ENSP00000362192
- ENST00000423407
- ENSP00000392795
- ENST00000426287
- ENSP00000412214
- H-SGK2
- dJ138B7.2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.95 | ||
protein domain | 0.92 | ||
cell type or tissue | 0.8 | ||
cell line | 0.64 | ||
small molecule perturbation | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.87 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 282 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.87 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 282 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0