Property Summary

NCBI Gene PubMed Count 16
PubMed Score 157.79
PubTator Score 14.96

Knowledge Summary

Patent (13,191)

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 3.18342873055583E-13
juvenile dermatomyositis 1189 5.48423558947813E-9
cystic fibrosis 1670 6.32349996063863E-9
lung adenocarcinoma 2714 7.74148181187805E-9
pilocytic astrocytoma 3086 6.91588403658604E-7
ulcerative colitis 2087 2.17677252334995E-6
posterior fossa group A ependymoma 1511 4.80577215729637E-6
lung cancer 4473 9.59586240122112E-6
interstitial cystitis 2299 3.17475856939331E-5
nephrosclerosis 329 8.77008738475932E-5
invasive ductal carcinoma 2950 1.15781725780791E-4
primary Sjogren syndrome 789 1.67880208036628E-4
ductal carcinoma in situ 1745 3.39517132936239E-4
pediatric high grade glioma 2712 4.81627983813718E-4
urothelial carcinoma 318 0.00435274628839353
gastric carcinoma 832 0.00513533490699624
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00564014154362364
glioblastoma 5572 0.00660799402829263
dermatomyositis 967 0.01553911051921
subependymal giant cell astrocytoma 2287 0.0156740935697213
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0278201235537643
ovarian cancer 8492 0.0340202187108736
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0340542323385807
mucosa-associated lymphoid tissue lymphoma 480 0.043321489138901
X-linked cerebral adrenoleukodystrophy 115 0.0476961109341708

Expression

Synonym

Accession Q9HBW9 B1AR71 Q5KU34
Symbols ETL
ELTD1
KPG_003

Gene

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA EggNOG
Cow OMA EggNOG
Opossum OMA EggNOG
Platypus OMA EggNOG
Chicken OMA EggNOG

 MGI Term (1)

 CSPA Cell Line (3)

Gene RIF (5)

PMID Text
26449464 miR-139-5p suppresses glioblastoma multiforme cell proliferation by targeting ELTD1 and regulating cell cycle.
23871637 Results provide insight into the regulation of tumor angiogenesis and highlight ELTD1 as key player in blood vessel formation.
23474535 Two of these (D1S0818i-ELTD1 and D6S0035i-MAPK14) remain associated following application of Bonferroni's correction and multivariate analysis.
23096411 Results of this study strongly suggests that associative analysis was able to accurately identify ELTD1 as a putative glioma-associated biomarker
18519829 Genes such as ELTD1 on chromosome 1, in addition to genes on chromosomes 4 (eg, GABRA2) and 6 (eg, CNR1), may be associated with the genetic risk for cannabis use disorders.

AA Sequence

MKRLPLLVVFSTLLNCSYTQNCTKTPCLPNAKCEIRNGIEACYCNMGFSGNGVTICEDDNECGNLTQSCG      1 - 70
ENANCTNTEGSYYCMCVPGFRSSSNQDRFITNDGTVCIENVNANCHLDNVCIAANINKTLTKIRSIKEPV     71 - 140
ALLQEVYRNSVTDLSPTDIITYIEILAESSSLLGYKNNTISAKDTLSNSTLTEFVKTVNNFVQRDTFVVW    141 - 210
DKLSVNHRRTHLTKLMHTVEQATLRISQSFQKTTEFDTNSTDIALKVFFFDSYNMKHIHPHMNMDGDYIN    211 - 280
IFPKRKAAYDSNGNVAVAFVYYKSIGPLLSSSDNFLLKPQNYDNSEEEERVISSVISVSMSSNPPTLYEL    281 - 350
EKITFTLSHRKVTDRYRSLCAFWNYSPDTMNGSWSSEGCELTYSNETHTSCRCNHLTHFAILMSSGPSIG    351 - 420
IKDYNILTRITQLGIIISLICLAICIFTFWFFSEIQSTRTTIHKNLCCSLFLAELVFLVGINTNTNKLFC    421 - 490
SIIAGLLHYFFLAAFAWMCIEGIHLYLIVVGVIYNKGFLHKNFYIFGYLSPAVVVGFSAALGYRYYGTTK    491 - 560
VCWLSTENNFIWSFIGPACLIILVNLLAFGVIIYKVFRHTAGLKPEVSCFENIRSCARGALALLFLLGTT    561 - 630
WIFGVLHVVHASVVTAYLFTVSNAFQGMFIFLFLCVLSRKIQEEYYRLFKNVPCCFGCLR              631 - 690
//

Text Mined References (17)

PMID Year Title
26449464 2015 MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme.
25713288 2015 International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.
23871637 2013 A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.
23474535 2013 Microsatellite scanning of the immunogenome associates MAPK14 and ELTD1 with graft-versus-host disease in hematopoietic stem cell transplantation.
23453885 2013 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
23096411 2013 ELTD1, a potential new biomarker for gliomas.
21782286 2011 A genome-wide association study of aging.
18519829 2008 An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
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