Tbio ETNK1 Ethanolamine kinase 1

Protein Summary

Description

Highly specific for ethanolamine phosphorylation. May be a rate-controlling step in phosphatidylethanolamine biosynthesis. This gene encodes an ethanolamine kinase, which functions in the first committed step of the phosphatidylethanolamine synthesis pathway. This cytosolic enzyme is specific for ethanolamine and exhibits negligible kinase activity on choline. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HBU6
• G5E969
• EKI 1

Gene Name

• ETNK1

Ensembl ID

• ENST00000266517
• ENSP00000266517
• ENSG00000139163
• ENST00000335148
• ENSP00000334041

Symbol

• EKI1
• EKI
• EKI1
• EKI 1
• Nbla10396

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
molecular function	0.9
microRNA	0.84
transcription factor binding site profile	0.77
transcription factor	0.68

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Ethanolamine Kinase 1

DTO Classes

Protein / Kinase / Unclassified Protein / Ethanolamine Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.41   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 198   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.41   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0