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Tbio
RHOF
Rho-related GTP-binding protein RhoF

Protein Summary
Description
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Causes the formation of thin, actin-rich surface projections called filopodia. Functions cooperatively with CDC42 and Rac to generate additional structures, increasing the diversity of actin-based morphology.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267205
  • ENSP00000267205
  • ENSG00000139725
  • ENST00000537171
  • ENSP00000477391

Symbol
  • ARHF
  • RIF
  • RIF
  • ARHF
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.98
molecular function
0.9
interacting protein
0.77
PubMedID
0.7
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.51   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.51   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0