Tbio ATP6V0A4 V-type proton ATPase 116 kDa subunit a isoform 4

Protein Summary

Description

Part of the proton channel of the V-ATPase that is involved in normal vectorial acid transport into the urine by the kidney. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HBG4
• A4D1R4
• A8KA80
• Q32M47
• V-ATPase 116 kDa isoform a4

Gene Name

• ATP6V0A4

Ensembl ID

• ENST00000310018
• ENSP00000308122
• ENSG00000105929
• ENST00000353492
• ENSP00000253856
• ENST00000393054
• ENSP00000376774
• ENST00000645515
• ENSP00000496421

Symbol

• ATP6N1B
• ATP6N2
• A4
• STV1
• VPH1
• VPP2
• RTA1C
• RTADR
• ATP6N2
• RDRTA2
• ATP6N1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
biological process	0.94
trait	0.75
gene perturbation	0.7
kinase perturbation	0.66

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase 116 Kda Subunit A Isoform 4

Protein / Hydrolase / V-type Proton Atpase 116 Kda Subunit A Isoform 4

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase 116 Kda Subunit A Isoform 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 113   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.16   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0