Tbio ZFYVE1 Zinc finger FYVE domain-containing protein 1

Protein Summary

Description

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Uniprot Accession IDs

• Q9HBF4
• J3KNL9
• Q8WYX7
• Q96K57
• Q9BXP9
• Q9HCI3

Gene Name

• ZFYVE1

Ensembl ID

• ENST00000318876
• ENSP00000326921
• ENSG00000165861
• ENST00000394207
• ENSP00000377757
• ENST00000555072
• ENSP00000452232
• ENST00000556143
• ENSP00000450742

Symbol

• DFCP1
• KIAA1589
• TAFF1
• ZNFN2A1
• SR3
• DFCP1
• TAFF1
• ZNFN2A1
• PPP1R172

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phenotype	0.86
transcription factor	0.8
cell type or tissue	0.74
protein domain	0.73
cellular component	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.32   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 152   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 367.32   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0