Property Summary

NCBI Gene PubMed Count 23
Grant Count 11
R01 Count 5
Funding $782,482.25
PubMed Score 95.04
PubTator Score 31.11

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
oligodendroglioma 1.200 0.000
psoriasis -2.100 0.000
osteosarcoma -1.334 0.001
ependymoma 1.100 0.000
group 4 medulloblastoma 2.300 0.000
astrocytoma 1.100 0.033
atypical teratoid / rhabdoid tumor 1.500 0.000
glioblastoma 1.100 0.017
medulloblastoma, large-cell 2.200 0.000
primitive neuroectodermal tumor 1.600 0.000
lung cancer 1.600 0.000

Gene RIF (12)

PMID Text
25755280 Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation.
25595894 Loss of PATZ1 expression is associated with thyroid cancer progression.
24380431 these results propose that Patz1 is important for ESC pluripotency.
24336083 The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis.
22493480 disruption of one or both Patz1 alleles may favor lymphomagenesis by activating the BCL6 pathway
22052190 PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.
20677143 Observational study of gene-disease association. (HuGE Navigator)
20026299 these results showed a potentially novel mechanism of cAMP signaling mediated through the interaction of RIalpha with PATZ1.
18401526 The results show that ZNF278 promotes cell growth, and its knockdown suppresses cell proliferation. ZNF278 could be a potential proto-oncogene in colorectal cancer.
11751862 MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF
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AA Sequence

MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVF      1 - 70
SAQLGDGGAADGGPADVGGATAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAA     71 - 140
KFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAALAANSNGIAGSMQPEE    141 - 210
EAARAAGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPSVASSAPPLTGKRGRGRPRKANLLDSMF    211 - 280
GSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSR    281 - 350
TRKQVACEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQSCGK    351 - 420
GFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHS    421 - 490
EGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDPIE    491 - 560
SSDSYGDLSDASDLKTPEKQSANGSFSCDMAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVR    561 - 630
ALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPMGPEGK                 631 - 687
//

Text Mined References (25)

PMID Year Title
25755280 2015 PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function.
25595894 2015 PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration.
24380431 2014 Patz1 regulates embryonic stem cell identity.
24336083 2013 PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22493480 2012 POZ-, AT-hook-, and zinc finger-containing protein (PATZ) interacts with human oncogene B cell lymphoma 6 (BCL6) and is required for its negative autoregulation.
22052190 2012 POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway.
20677143 2010 [Association of single nucleotide polymorphisms of PATZ1 gene with azoospermia].
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20026299 2010 Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).
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