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Tbio
PLEKHA3
Pleckstrin homology domain-containing family A member 3

Protein Summary
Description
Involved in Golgi to cell surface membrane traffic. Induces membrane tubulation. Binds preferentially to phosphatidylinositol 4-phosphate (PtdIns4P).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000234453
  • ENSP00000234453
  • ENSG00000116095

Symbol
  • FAPP1
  • FAPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
histone modification site profile
0.75
tissue sample
0.73
transcription factor binding site profile
0.68
gene perturbation
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.75   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0