Tchem | Elongation of very long chain fatty acids protein 3 |
This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 3.77682753100748E-41 |
Atopic dermatitis | 944 | 0.0161563049540675 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Simpson-Golabi-Behmel syndrome | 17 | 3.187 | 1.6 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Horse | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG Inparanoid |
Opossum | EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
C. elegans | OMA Inparanoid |
S.cerevisiae | OMA Inparanoid |
CHEMBL491944
pIC50 6.30
CHEMBL490110
pIC50 6.43
CHEMBL449121
pIC50 6.47
CHEMBL490750
pIC50 6.66
CHEMBL570571
pIC50 6.89
CHEMBL493642
pIC50 7.23
MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILW 1 - 70 SFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRP 71 - 140 LIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQM 141 - 210 FVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ 211 - 270 //
PMID | Year | Title |
---|---|---|
20937905 | 2010 | ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis. |
17583696 | 2007 | ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells. |
17207965 | 2007 | hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15164054 | 2004 | The DNA sequence and comparative analysis of human chromosome 10. |
14581464 | 2004 | Role for ELOVL3 and fatty acid chain length in development of hair and skin function. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
10970790 | 2000 | Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids. |
10429212 | 1999 | N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments. |
8944226 | 1996 | Biosynthesis of triacylglycerols. |