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  5. Elongation of very long chain fatty acids protein 3

Tchem Elongation of very long chain fatty acids protein 3

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 17.45
PubTator Score 3.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (2)

Disease Target Count P-value
psoriasis 6685 3.77682753100748E-41
Atopic dermatitis 944 0.0161563049540675
Disease Target Count Z-score Confidence
Simpson-Golabi-Behmel syndrome 17 3.187 1.6

Expression

  Differential Expression (2)

Disease log2 FC p
Atopic dermatitis -2.600 0.016
psoriasis -3.400 0.000

Synonym

Accession Q9HB03 Q5VZL3 Q8N180
Symbols CIG30
CIG-30

Gene

ELOVL3

PANTHER Protein Class (2)

  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
C. elegans OMA Inparanoid
S.cerevisiae OMA Inparanoid

 GO Function (4)

 GO Component (3)

 GO Process (9)

 Compartment GO Term (27)

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 MGI Term (6)

 HCA RNA Cell Line (50)

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Pathway (13)

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 UniProt Keyword (12)

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Ligand (6)  

Structure of CHEMBL491944

CHEMBL491944
pIC50 6.30

Structure of CHEMBL490110

CHEMBL490110
pIC50 6.43

Structure of CHEMBL449121

CHEMBL449121
pIC50 6.47

Structure of CHEMBL490750

CHEMBL490750
pIC50 6.66

Structure of CHEMBL570571

CHEMBL570571
pIC50 6.89

Structure of CHEMBL493642

CHEMBL493642
pIC50 7.23

AA Sequence 

MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILW      1 - 70
SFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRP     71 - 140
LIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQM    141 - 210
FVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ              211 - 270
//

Text Mined References (10)

PMID Year Title
20937905 2010 ELOVL1 production of C24 acyl-CoAs is linked to C24 sphingolipid synthesis.
17583696 2007 ELOVL2 overexpression enhances triacylglycerol synthesis in 3T3-L1 and F442A cells.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15164054 2004 The DNA sequence and comparative analysis of human chromosome 10.
14581464 2004 Role for ELOVL3 and fatty acid chain length in development of hair and skin function.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10970790 2000 Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.
10429212 1999 N-tail translocation in a eukaryotic polytopic membrane protein: synergy between neighboring transmembrane segments.
8944226 1996 Biosynthesis of triacylglycerols.