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  5. Elongation of very long chain fatty acids protein 3

Tchem Elongation of very long chain fatty acids protein 3

Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

This gene encodes a protein that belongs to the GNS1/SUR4 family. Members of this family play a role in elongation of long chain fatty acids to provide precursors for synthesis of sphingolipids and ceramides. [provided by RefSeq, Jul 2013]

 Comments

Property Summary

Ligand Count 6
NCBI Gene PubMed Count 9
PubMed Score 18.81
PubTator Score 3.26

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count P-value
psoriasis 6694 4.2e-14
Atopic dermatitis 952 1.6e-02
Disease Target Count Z-score Confidence
Simpson-Golabi-Behmel syndrome 19 3.03 1.5

Expression

  Differential Expression (2)

Disease log2 FC p
Atopic dermatitis -2.600 1.6e-02
psoriasis -2.700 4.2e-14

Synonym

Accession Q9HB03 Q5VZL3 Q8N180
Symbols CIG30
CIG-30

Gene

ELOVL3

PANTHER Protein Class (2)

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG

 UniProt Keyword (12)

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 GO Function (5)

 GO Component (3)

 GO Process (9)

 Compartment GO Term (27)

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 MGI Phenotype (6)

 GWAS Trait (5)

 HCA RNA Cell Line (50)

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Pathway (11)

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Ligand (6)

Structure of CHEMBL491944

CHEMBL491944
pIC50 6.30

Structure of CHEMBL490110

CHEMBL490110
pIC50 6.43

Structure of CHEMBL449121

CHEMBL449121
pIC50 6.47

Structure of CHEMBL490750

CHEMBL490750
pIC50 6.66

Structure of CHEMBL570571

CHEMBL570571
pIC50 6.89

Structure of CHEMBL493642

CHEMBL493642
pIC50 7.23

AA Sequence 

MVTAMNVSHEVNQLFQPYNFELSKDMRPFFEEYWATSFPIALIYLVLIAVGQNYMKERKGFNLQGPLILW      1 - 70
SFCLAIFSILGAVRMWGIMGTVLLTGGLKQTVCFINFIDNSTVKFWSWVFLLSKVIELGDTAFIILRKRP     71 - 140
LIFIHWYHHSTVLVYTSFGYKNKVPAGGWFVTMNFGVHAIMYTYYTLKAANVKPPKMLPMLITSLQILQM    141 - 210
FVGAIVSILTYIWRQDQGCHTTMEHLFWSFILYMTYFILFAHFFCQTYIRPKVKAKTKSQ              211 - 270
//

Text Mined References (10)

PMID Year Title