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Tbio
SLC52A2
Solute carrier family 52, riboflavin transporter, member 2

Protein Summary
Description
Riboflavin transporter. Riboflavin transport is Na(+)-independent but moderately pH-sensitive. Activity is strongly inhibited by riboflavin analogs, such as lumiflavin. Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN). In case of infection by retroviruses, acts as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A). This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329994
  • ENSP00000333638
  • ENSG00000185803
  • ENST00000402965
  • ENSP00000385961
  • ENST00000527078
  • ENSP00000434728
  • ENST00000530047
  • ENSP00000435820
  • ENST00000532887
  • ENSP00000436768
  • ENST00000642477
  • ENSP00000496439
  • ENSG00000285112
  • ENST00000643944
  • ENSP00000496184
  • ENST00000644059
  • ENSP00000494426
  • ENST00000644819
  • ENSP00000495046
  • ENST00000645040
  • ENSP00000495874
  • ENST00000645386
  • ENSP00000495049
  • ENST00000646034
  • ENSP00000495788

Symbol
  • GPR172A
  • PAR1
  • RFT3
  • PAR1
  • RFT3
  • RFVT2
  • hRFT3
  • BVVLS2
  • GPCR41
  • GPR172A
  • D15Ertd747e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
histone modification site profile
0.92
kinase perturbation
0.76
disease perturbation
0.68
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.56   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.56   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0