Tbio UCK1 Uridine-cytidine kinase 1

Protein Summary

Description

Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine. This gene encodes a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• Q9HA47
• Q5JT09
• Q5JT10
• Q5JT12
• Q5JT13
• Q6IA74
• Q96BJ0
• UCK 1

Gene Name

• UCK1

Ensembl ID

• ENST00000372208
• ENSP00000361282
• ENSG00000130717
• ENST00000372210
• ENSP00000361284
• ENST00000372211
• ENSP00000361285
• ENST00000372215
• ENSP00000361289

Symbol

• URK1
• URK1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.9
tissue sample	0.7
biological process	0.67
histone modification site profile	0.66
tissue	0.61

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Nucleotide Kinase / Uridine-cytidine Kinase 1

Protein / Transferase / Glycosyltransferase / Uridine-cytidine Kinase 1

DTO Classes

Protein / Kinase / Non-protein Kinase / Nucleoside Kinase / Uridine Kinase Family / Uridine-cytidine Kinase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.47   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0