Property Summary

NCBI Gene PubMed Count 24
PubMed Score 5.61
PubTator Score 0.50

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (1)

Disease Target Count P-value
non-small cell lung cancer 2798 4.76895484933881E-15
osteosarcoma 7933 2.31140935074131E-7
Pick disease 1893 2.89072024992346E-7
atypical teratoid/rhabdoid tumor 1095 3.68505155006099E-6
pediatric high grade glioma 2712 3.71862359059324E-6
glioblastoma 5572 7.7164811246919E-6
ovarian cancer 8492 1.08046325578297E-5
hepatocellular carcinoma 550 2.04194406814121E-5
acute quadriplegic myopathy 1157 6.1153043925413E-5
medulloblastoma, large-cell 6234 7.05931146356891E-5
primitive neuroectodermal tumor 3031 7.23379280187969E-5
nasopharyngeal carcinoma 1056 0.00107257848921103
gastric cancer 436 0.0010794391086993
group 3 medulloblastoma 2254 0.0011749750094422
pancreatic carcinoma 567 0.00145779738182505
pancreatic cancer 2300 0.00145779738182507
oligodendroglioma 2849 0.00390519272584086
ependymoma 2514 0.0071769064145591
astrocytic glioma 2241 0.0101010444675503
Multiple myeloma 1328 0.0104437331043373
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0107760464555311

Expression

  Differential Expression (21)

Gene RIF (4)

PMID Text
18194663 The average FIX expression level of the rDNA recombinants was additionally enhanced to that from a strong Pol II promoter as a result of elimination of position effects.
17499043 Human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I-dependent transcription in human glioblastoma lines.
16880508 CK2 has the potential to regulate Pol I transcription at multiple levels, in preinitiation complex (PIC) formation, activation, and reinitiation of transcription.
16055704 PTEN represses RNA Pol I transcription through a novel mechanism that involves disruption of the SL1 complex

AA Sequence

MDPGSRWRNLPSGPSLKHLTDPSYGIPREQQKAALQELTRAHVESFNYAVHEGLGLAVQAIPPFEFAFKD      1 - 70
ERISFTILDAVISPPTVPKGTICKEANVYPAECRGRRSTYRGKLTADINWAVNGISKGIIKQFLGYVPIM     71 - 140
VKSKLCNLRNLPPQALIEHHEEAEEMGGYFIINGIEKVIRMLIMPRRNFPIAMIRPKWKTRGPGYTQYGV    141 - 210
SMHCVREEHSAVNMNLHYLENGTVMLNFIYRKELFFLPLGFALKALVSFSDYQIFQELIKGKEDDSFLRN    211 - 280
SVSQMLRIVMEEGCSTQKQVLNYLGECFRVKLNVPDWYPNEQAAEFLFNQCICIHLKSNTEKFYMLCLMT    281 - 350
RKLFALAKGECMEDNPDSLVNQEVLTPGQLFLMFLKEKLEGWLVSIKIAFDKKAQKTSVSMNTDNLMRIF    351 - 420
TMGIDLTKPFEYLFATGNLRSKTGLGLLQDSGLCVVADKLNFIRYLSHFRCVHRGADFAKMRTTTVRRLL    421 - 490
PESWGFLCPVHTPDGEPCGLMNHLTAVCEVVTQFVYTASIPALLCNLGVTPIDGAPHRSYSECYPVLLDG    491 - 560
VMVGWVDKDLAPGIADSLRHFKVLREKRIPPWMEVVLIPMTGKPSLYPGLFLFTTPCRLVRPVQNLALGK    561 - 630
EELIGTMEQIFMNVAIFEDEVFAGVTTHQELFPHSLLSVIANFIPFSDHNQSPRNMYQCQMGKQTMGFPL    631 - 700
LTYQDRSDNKLYRLQTPQSPLVRPSMYDYYDMDNYPIGTNAIVAVISYTGYDMEDAMIVNKASWERGFAH    701 - 770
GSVYKSEFIDLSEKIKQGDSSLVFGIKPGDPRVLQKLDDDGLPFIGAKLQYGDPYYSYLNLNTGESFVMY    771 - 840
YKSKENCVVDNIKVCSNDTGSGKFKCVCITMRVPRNPTIGDKFASRHGQKGILSRLWPAEDMPFTESGMV    841 - 910
PDILFNPHGFPSRMTIGMLIESMAGKSAALHGLCHDATPFIFSEENSALEYFGEMLKAAGYNFYGTERLY    911 - 980
SGISGLELEADIFIGVVYYQRLRHMVSDKFQVRTTGARDRVTNQPIGGRNVQGGIRFGEMERDALLAHGT    981 - 1050
SFLLHDRLFNCSDRSVAHVCVKCGSLLSPLLEKPPPSWSAMRNRKYNCTLCSRSDTIDTVSVPYVFRYFV   1051 - 1120
AELAAMNIKVKLDVV                                                          1121 - 1135
//

Text Mined References (28)

PMID Year Title
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21269460 2011 Initial characterization of the human central proteome.
20208542 2010 PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.
19214185 2009 FACT facilitates chromatin transcription by RNA polymerases I and III.
18194663 2008 Efficient protein expression from the endogenous RNA polymerase I promoter using a human ribosomal DNA targeting vector.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17499043 2007 Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.
17474147 2007 Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.
16880508 2006 Casein kinase 2 associates with initiation-competent RNA polymerase I and has multiple roles in ribosomal DNA transcription.
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