SEC61A2
Protein transport protein Sec61 subunit alpha isoform 2
Protein Summary
Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins. Found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins (By similarity). The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
- ENST00000298428
- ENSP00000298428
- ENSG00000065665
- ENST00000304267
- ENSP00000302048
- ENST00000379033
- ENSP00000368319
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.97 | ||
histone modification site profile | 0.91 | ||
transcription factor perturbation | 0.68 | ||
small molecule perturbation | 0.67 | ||
microRNA | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.51 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 3 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 0.51 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 3 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0