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Tbio
AKIRIN1
Akirin-1

Protein Summary
Description
Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulates chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432648
  • ENSP00000392678
  • ENSG00000174574
  • ENST00000446189
  • ENSP00000389866

Symbol
  • C1orf108
  • STRF2
  • C1orf108
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
cell type or tissue
0.84
transcription factor perturbation
0.8
transcription factor binding site profile
0.79
transcription factor
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0