| Tbio | Protein argonaute-3 |
Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. Proposed to be involved in stabilization of small RNA derivates (riRNA) derived from processed RNA polymerase III-transcribed Alu repeats containing a DR2 retinoic acid response element (RARE) in stem cells and in the subsequent riRNA-dependent degradation of a subset of RNA polymerase II-transcribed coding mRNAs by recruiting a mRNA decapping complex involving EDC4.
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, contains a PAZ domain and a PIWI domain, and may play a role in short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a tandem cluster of closely related family members including argonaute 4 and eukaryotic translation initiation factor 2C, 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 1.6e-09 |
| osteosarcoma | 7950 | 2.4e-06 |
| Pick disease | 1894 | 1.0e-05 |
| medulloblastoma, large-cell | 6241 | 4.9e-04 |
| pituitary cancer | 1972 | 8.9e-04 |
| atypical teratoid / rhabdoid tumor | 5112 | 9.3e-04 |
| pancreatic carcinoma | 562 | 1.1e-03 |
| pancreatic cancer | 2398 | 1.1e-03 |
| glioblastoma | 5792 | 3.5e-03 |
| astrocytic glioma | 2597 | 1.3e-02 |
| Rheumatoid arthritis | 1191 | 1.4e-02 |
| tuberculosis and treatment for 6 months | 409 | 1.7e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Chikungunya | 16 | 3.454 | 1.7 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytic glioma | 1.700 | 1.3e-02 |
| atypical teratoid / rhabdoid tumor | 1.600 | 9.3e-04 |
| glioblastoma | -1.200 | 3.5e-03 |
| medulloblastoma, large-cell | -1.400 | 4.9e-04 |
| osteosarcoma | 1.510 | 2.4e-06 |
| pancreatic cancer | 1.100 | 1.1e-03 |
| pancreatic carcinoma | 1.100 | 1.1e-03 |
| Pick disease | 2.100 | 1.0e-05 |
| pituitary cancer | -1.600 | 8.9e-04 |
| psoriasis | -1.100 | 1.6e-09 |
| Rheumatoid arthritis | 1.800 | 1.4e-02 |
| tuberculosis and treatment for 6 months | -1.100 | 1.7e-02 |
MEIGSAGPAGAQPLLMVPRRPGYGTMGKPIKLLANCFQVEIPKIDVYLYEVDIKPDKCPRRVNREVVDSM 1 - 70 VQHFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVTLPGEGGKDRPFKVSIKFVSRVSWHLLHEVL 71 - 140 TGRTLPEPLELDKPISTNPVHAVDVVLRHLPSMKYTPVGRSFFSAPEGYDHPLGGGREVWFGFHQSVRPA 141 - 210 MWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKGLKVEVTHCGTMRRKY 211 - 280 RVCNVTRRPASHQTFPLQLENGQTVERTVAQYFREKYTLQLKYPHLPCLQVGQEQKHTYLPLEVCNIVAG 281 - 350 QRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKVRDEMAHVTGRVLPAPMLQ 351 - 420 YGGRNRTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQCREEILKGFTDQLRKISKDAGMPIQGQP 421 - 490 CFCKYAQGADSVEPMFRHLKNTYSGLQLIIVILPGKTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQT 491 - 560 LSNLCLKINVKLGGINNILVPHQRPSVFQQPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPSRYCATV 561 - 630 RVQRPRQEIIQDLASMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDYQ 631 - 700 PGITYIVVQKRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLW 701 - 770 DDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEHDSAEGSHVSGQSNGRDP 771 - 840 QALAKAVQIHQDTLRTMYFA 841 - 860 //
