Tbio | Conserved oligomeric Golgi complex subunit 4 |
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Comments
Disease | Target Count |
---|---|
CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj | 1 |
Precancerous Conditions | 69 |
Disease | Target Count | P-value |
---|---|---|
ovarian cancer | 8492 | 8.50149228558226E-7 |
diabetes mellitus | 1663 | 0.00166924601572823 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Congenital disorder of glycosylation | 53 | 3.577 | 1.8 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Oculocerebrorenal syndrome | 24 | 3.631 | 1.8 |
Disease | Target Count |
---|---|
Congenital disorder of glycosylation 2J | 1 |
Disease | log2 FC | p |
---|---|---|
diabetes mellitus | -1.200 | 0.002 |
ovarian cancer | 1.300 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Macaque | OMA EggNOG Inparanoid |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Opossum | EggNOG Inparanoid |
Platypus | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
C. elegans | OMA Inparanoid |
Fruitfly | OMA EggNOG Inparanoid |
S.cerevisiae | OMA EggNOG Inparanoid |
PMID | Text |
---|---|
19651599 | The 1.9 A crystal structure of a Cog4 C-terminal fragment, was determined. Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4's small C-terminal domain. |
19536132 | Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site. |
19494034 | A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II. |
18187620 | Knockdown of component of oligomeric golgi complex 4 (COG4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTI 1 - 70 ESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMD 71 - 140 GVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEG 141 - 210 DLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIA 211 - 280 RIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPR 281 - 350 ELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLY 351 - 420 VTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFR 421 - 490 DVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENIST 491 - 560 LKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSV 561 - 630 SHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLG 631 - 700 GLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLA 701 - 770 LRIDFRSEDIKRLRL 771 - 785 //
PMID | Year | Title |
---|---|---|
25231870 | 2014 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
21269460 | 2011 | Initial characterization of the human central proteome. |
19651599 | 2009 | Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. |
19536132 | 2009 | Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. |
19494034 | 2009 | Golgi function and dysfunction in the first COG4-deficient CDG type II patient. |
19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
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