| Tbio | Conserved oligomeric Golgi complex subunit 4 |
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Comments
| Disease | Target Count |
|---|---|
| CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj | 1 |
| Precancerous Conditions | 69 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8492 | 8.50149228558226E-7 |
| diabetes mellitus | 1663 | 0.00166924601572823 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital disorder of glycosylation | 53 | 3.577 | 1.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Oculocerebrorenal syndrome | 24 | 3.631 | 1.8 |
| Disease | Target Count |
|---|---|
| Congenital disorder of glycosylation 2J | 1 |
| Disease | log2 FC | p |
|---|---|---|
| diabetes mellitus | -1.200 | 0.002 |
| ovarian cancer | 1.300 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Macaque | OMA EggNOG Inparanoid |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Opossum | EggNOG Inparanoid |
| Platypus | OMA EggNOG Inparanoid |
| Chicken | OMA EggNOG Inparanoid |
| Anole lizard | OMA EggNOG Inparanoid |
| Xenopus | OMA EggNOG Inparanoid |
| C. elegans | OMA Inparanoid |
| Fruitfly | OMA EggNOG Inparanoid |
| S.cerevisiae | OMA EggNOG Inparanoid |
| PMID | Text |
|---|---|
| 19651599 | The 1.9 A crystal structure of a Cog4 C-terminal fragment, was determined. Arg 729 is found to occupy a key position at the center of a salt bridge network, thereby stabilizing Cog4's small C-terminal domain. |
| 19536132 | Study shows that the SM protein, Sly1, interacts directly with the conserved oligomeric Golgi (COG) tethering complex; Sly1-COG interaction is mediated by the Cog4 subunit, which also interacts with Syntaxin 5 through a different binding site. |
| 19494034 | A novel R729W missense mutation in COG4 was associated with the congenital disorder of glycosylation type II. |
| 18187620 | Knockdown of component of oligomeric golgi complex 4 (COG4) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells |
MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTI 1 - 70 ESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMD 71 - 140 GVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEG 141 - 210 DLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIA 211 - 280 RIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPR 281 - 350 ELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLY 351 - 420 VTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFR 421 - 490 DVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENIST 491 - 560 LKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSV 561 - 630 SHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLG 631 - 700 GLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLA 701 - 770 LRIDFRSEDIKRLRL 771 - 785 //
| PMID | Year | Title |
|---|---|---|
| 25231870 | 2014 | Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. |
| 23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
| 22814378 | 2012 | N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. |
| 21269460 | 2011 | Initial characterization of the human central proteome. |
| 19651599 | 2009 | Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene. |
| 19536132 | 2009 | Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing. |
| 19494034 | 2009 | Golgi function and dysfunction in the first COG4-deficient CDG type II patient. |
| 19413330 | 2009 | Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. |
| 17974005 | 2007 | The full-ORF clone resource of the German cDNA Consortium. |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |
| More... |
