| Tbio | Conserved oligomeric Golgi complex subunit 4 |
Required for normal Golgi function. Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1.
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
The protein encoded by this gene is a component of an oligomeric protein complex involved in the structure and function of the Golgi apparatus. Defects in this gene may be a cause of congenital disorder of glycosylation type IIj. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj | 1 | 0.0 | 0.0 |
| Precancerous Conditions | 80 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 8.5e-07 |
| diabetes mellitus | 1728 | 1.7e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital disorder of glycosylation | 54 | 3.576 | 1.8 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Oculocerebrorenal syndrome | 29 | 3.253 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| diabetes mellitus | -1.200 | 1.7e-03 |
| ovarian cancer | 1.300 | 8.5e-07 |
MADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTI 1 - 70 ESKMVTLHRMGPNLQLIEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMD 71 - 140 GVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGKEGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEG 141 - 210 DLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAVIFADTLTLLFEGIA 211 - 280 RIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPR 281 - 350 ELDPILTEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLY 351 - 420 VTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFR 421 - 490 DVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENIST 491 - 560 LKKTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSV 561 - 630 SHNIEEEEFNDYEANDPWVQQFILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLG 631 - 700 GLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERVTEILDYWGPNSGPLTWRLTPAEVRQVLA 701 - 770 LRIDFRSEDIKRLRL 771 - 785 //
