| Tbio | Golgi reassembly-stacking protein 2 |
Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 1.5e-07 |
| osteosarcoma | 7950 | 7.8e-04 |
| Multiple myeloma | 1332 | 9.9e-04 |
| dermatomyositis | 966 | 1.4e-03 |
| lung cancer | 4740 | 2.3e-03 |
| astrocytoma | 1146 | 8.0e-03 |
| glioblastoma | 5792 | 2.6e-02 |
| non primary Sjogren syndrome sicca | 891 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Griscelli syndrome type 2 | 12 | 3.697 | 1.8 |
| Exudative vitreoretinopathy | 15 | 3.084 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| astrocytoma | 1.700 | 8.0e-03 |
| dermatomyositis | 1.100 | 1.4e-03 |
| glioblastoma | 1.300 | 2.6e-02 |
| lung cancer | 1.200 | 2.3e-03 |
| Multiple myeloma | 1.272 | 9.9e-04 |
| non primary Sjogren syndrome sicca | 1.200 | 4.0e-02 |
| osteosarcoma | 1.023 | 7.8e-04 |
| ovarian cancer | 4.100 | 1.5e-07 |
MGSSQSVEIPGGGTEGYHVLRVQENSPGHRAGLEPFFDFIVSINGSRLNKDNDTLKDLLKANVEKPVKML 1 - 70 IYSSKTLELRETSVTPSNLWGGQGLLGVSIRFCSFDGANENVWHVLEVESNSPAALAGLRPHSDYIIGAD 71 - 140 TVMNESEDLFSLIETHEAKPLKLYVYNTDTDNCREVIITPNSAWGGEGSLGCGIGYGYLHRIPTRPFEEG 141 - 210 KKISLPGQMAGTPITPLKDGFTEVQLSSVNPPSLSPPGTTGIEQSLTGLSISSTPPAVSSVLSTGVPTVP 211 - 280 LLPPQVNQSLTSVPPMNPATTLPGLMPLPAGLPNLPNLNLNLPAPHIMPGVGLPELVNPGLPPLPSMPPR 281 - 350 NLPGIAPLPLPSEFLPSFPLVPESSSAASSGELLSSLPPTSNAPSDPATTTAKADAASSLTVDVTPPTAK 351 - 420 APTTVEDRVGDSTPVSEKPVSAAVDANASESP 421 - 452 //
