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Tbio
PLEKHF2
Pleckstrin homology domain-containing family F member 2

Protein Summary
Description
May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315367
  • ENSP00000322373
  • ENSG00000175895
  • ENST00000519516
  • ENSP00000427792

Symbol
  • ZFYVE18
  • EAPF
  • PHAFIN2
  • ZFYVE18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
interacting protein
0.86
transcription factor binding site profile
0.86
protein domain
0.85
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 112   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.52   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0