Property Summary

NCBI Gene PubMed Count 30
PubMed Score 20.93
PubTator Score 29.52

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
lung carcinoma 2844 4.01603230305915E-23
breast carcinoma 1614 6.63896313085878E-23
ependymoma 2514 1.70815092767897E-7
osteosarcoma 7933 1.93175542824758E-7
pediatric high grade glioma 2712 1.76494529444369E-6
ovarian cancer 8492 2.66886935103802E-5
glioblastoma 5572 7.38680957258427E-5
psoriasis 6685 1.34706112637753E-4
sonic hedgehog group medulloblastoma 1482 1.80837057889448E-4
cutaneous lupus erythematosus 1056 0.00114416562019007
invasive ductal carcinoma 2950 0.00162456804653064
primitive neuroectodermal tumor 3031 0.00226245299330314
lung adenocarcinoma 2714 0.00515676377587911
pancreatic cancer 2300 0.00727702433838228
Rheumatoid Arthritis 1171 0.00754296491520156
primary Sjogren syndrome 789 0.00801610442655097
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0100349040061589
medulloblastoma, large-cell 6234 0.0123683625937618
Multiple myeloma 1328 0.0199169793485692
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0369606998536866
astrocytoma 1493 0.0388015636732
Disease Target Count Z-score Confidence
Duodenitis 8 3.434 1.7



Accession Q9H8S9 Q53S34 Q9H3T5 Q9HAI0 Q9NVE2
Symbols MOB1



5BRK   1PI1   4J1V   4JIZ   5BRM  

  Ortholog (8)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (7)

25031347 No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication.
23652010 The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade.
22454515 Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis.
19955215 Results suggest that Mob1 and the other mammalian orthologues of the mitotic exit network regulate mitotic progression by facilitating the timely mobilization of the chromosomal passenger complex to the spindle midzone.
19739119 hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells.
17611689 MATS1 mRNA expression is suppressed in tumor tissue and its low expression is associated with tumor growth, invasion and metastasis of colorectal cancer
15766530 Mats1 can rescue the lethality associated with loss of Mats function in Drosophila; As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans

AA Sequence

LGSKDR                                                                    211 - 216

Text Mined References (32)

PMID Year Title
26298709 2015 Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.
25852190 2015 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
25416956 2014 A proteome-scale map of the human interactome network.
25031347 2014 Seed sequence-matched controls reveal limitations of small interfering RNA knockdown in functional and structural studies of hepatitis C virus NS5A-MOBKL1B interaction.
24366813 2013 Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1.
24255178 2013 Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
23652010 2013 Proteolysis of MOB1 by the ubiquitin ligase praja2 attenuates Hippo signalling and supports glioblastoma growth.
23386615 2013 The tumor suppressor Mst1 promotes changes in the cellular redox state by phosphorylation and inactivation of peroxiredoxin-1 protein.
23376485 2013 Proteomic analysis of podocyte exosome-enriched fraction from normal human urine.
22814378 2012 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.