Tbio UBE2Z Ubiquitin-conjugating enzyme E2 Z

Protein Summary

Description

Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation. This gene encodes an enzyme which ubiquitinates proteins which participate in signaling pathways and apoptosis. [provided by RefSeq, Feb 2012]

Uniprot Accession IDs

• Q9H832
• A6N8M6
• A6NC60
• Q7L354
• Q8TCM4
• Q9H893

Gene Name

• UBE2Z

Ensembl ID

• ENST00000360943
• ENSP00000354201
• ENSG00000159202

Symbol

• USE1
• HOYS7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
virus perturbation	1
molecular function	0.95
transcription factor binding site profile	0.78
transcription factor perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.59   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0