| Tbio | Alpha-1,2-mannosyltransferase ALG9 |
Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides.
This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital disorder of glycosylation type 1L | 1 | 0.0 | 0.0 |
| Polycystic Kidney Disease, Potter Type I, with Microbrachycephaly, Hypertelorism, and Brachymelia | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.1e-07 |
| osteosarcoma | 7950 | 2.8e-05 |
| group 3 medulloblastoma | 4104 | 9.9e-04 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| subependymal giant cell astrocytoma | 2287 | 1.5e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 2.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital disorder of glycosylation | 54 | 4.165 | 2.1 |
| Disease | Target Count |
|---|---|
| ALG9-CDG | 1 |
| Gillessen-Kaesbach-Nishimura syndrome | 1 |
| Disease | log2 FC | p |
|---|---|---|
| group 3 medulloblastoma | 1.200 | 9.9e-04 |
| invasive ductal carcinoma | -1.100 | 1.2e-02 |
| osteosarcoma | -2.102 | 2.8e-05 |
| ovarian cancer | -1.800 | 3.1e-07 |
| pancreatic ductal adenocarcinoma liver m... | -1.083 | 2.5e-02 |
| subependymal giant cell astrocytoma | -1.068 | 1.5e-02 |
MASRGARQRLKGSGASSGDTAPAADKLRELLGSREAGGAEHRTELSGNKAGQVWAPEGSTAFKCLLSARL 1 - 70 CAALLSNISDCDETFNYWEPTHYLIYGEGFQTWEYSPAYAIRSYAYLLLHAWPAAFHARILQTNKILVFY 71 - 140 FLRCLLAFVSCICELYFYKAVCKKFGLHVSRMMLAFLVLSTGMFCSSSAFLPSSFCMYTTLIAMTGWYMD 141 - 210 KTSIAVLGVAAGAILGWPFSAALGLPIAFDLLVMKHRWKSFFHWSLMALILFLVPVVVIDSYYYGKLVIA 211 - 280 PLNIVLYNVFTPHGPDLYGTEPWYFYLINGFLNFNVAFALALLVLPLTSLMEYLLQRFHVQNLGHPYWLT 281 - 350 LAPMYIWFIIFFIQPHKEERFLFPVYPLICLCGAVALSALQKCYHFVFQRYRLEHYTVTSNWLALGTVFL 351 - 420 FGLLSFSRSVALFRGYHGPLDLYPEFYRIATDPTIHTVPEGRPVNVCVGKEWYRFPSSFLLPDNWQLQFI 421 - 490 PSEFRGQLPKPFAEGPLATRIVPTDMNDQNLEEPSRYIDISKCHYLVDLDTMRETPREPKYSSNKEEWIS 491 - 560 LAYRPFLDASRSSKLLRAFYVPFLSDQYTVYVNYTILKPRKAKQIRKKSGG 561 - 611 //
