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Tbio
BCAS3
Breast carcinoma-amplified sequence 3

Protein Summary
Description
Plays a role in angiogenesis. Participates in the regulation of cell polarity and directional endothelial cell migration by mediating both the activation and recruitment of CDC42 and the reorganization of the actin cytoskeleton at the cell leading edge. Promotes filipodia formation (By similarity). Functions synergistically with PELP1 as a transcriptional coactivator of estrogen receptor-responsive genes. Stimulates histone acetyltransferase activity. Binds to chromatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000390652
  • ENSP00000375067
  • ENSG00000141376
  • ENST00000407086
  • ENSP00000385323
  • ENST00000408905
  • ENSP00000386173
  • ENST00000588462
  • ENSP00000468592
  • ENST00000588874
  • ENSP00000464825
  • ENST00000589222
  • ENSP00000466078

Symbol
  • MAAB
  • GAOB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
trait
0.93
histone modification site profile
0.89
transcription factor binding site profile
0.85
phenotype
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.18   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0