EPS8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2
Protein Summary
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]
- ENST00000318562
- ENSP00000320828
- ENSG00000177106
- ENST00000526198
- ENSP00000436230
- ENST00000530636
- ENSP00000436035
- ENST00000533256
- ENSP00000435585
- ENST00000614442
- ENSP00000480201
- EPS8R2
- EPS8R2
- DFNB106
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.97 | ||
kinase perturbation | 0.81 | ||
transcription factor | 0.59 | ||
cellular component | 0.58 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.52 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 234 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4.52 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 234 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0