TMEM231
Transmembrane protein 231
Protein Summary
Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity). This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
- ENST00000258173
- ENSP00000258173
- ENSG00000205084
- ENST00000568377
- ENSP00000476267
- MKS11
- JBTS20
- ALYE870
- PRO1886
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
phenotype | 0.64 | ||
virus perturbation | 0.59 | ||
tissue | 0.58 | ||
disease perturbation | 0.56 | ||
transcription factor binding site profile | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.83 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.83 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0