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Tbio Coiled-coil domain-containing protein 134

In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

 Comments

Property Summary

NCBI Gene PubMed Count 12
PubMed Score 3.96
PubTator Score 4.49

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (2)

Disease Target Count Z-score Confidence
Liver neoplasms 130 0.0 0.0
Precancerous Conditions 80 0.0 0.0
Disease Target Count Z-score Confidence
Alzheimer's disease 658 0.0 1.7

Expression

Synonym

Accession Q9H6E4
Symbols

Gene

CCDC134

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (9)

 GO Component (4)

 Compartment GO Term (15)

 IMPC Phenotype (1)

 MGI Phenotype (9)

 GWAS Trait (4)

 HCA RNA Cell Line (56)

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Gene RIF (5)

AA Sequence 

MDLLQFLAFLFVLLLSGMGATGTLRTSLDPSLEIYKKMFEVKRREQLLALKNLAQLNDIHQQYKILDVML      1 - 70
KGLFKVLEDSRTVLTAADVLPDGPFPQDEKLKDAFSHVVENTAFFGDVVLRFPRIVHYYFDHNSNWNLLI     71 - 140
RWGISFCNQTGVFNQGPHSPILSLMAQELGISEKDSNFQNPFKIDRTEFIPSTDPFQKALREEEKRRKKE    141 - 210
EKRKEIRKGPRISRSQSEL                                                       211 - 229
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Text Mined References (14)

PMID Year Title