Tbio EPHX3 Epoxide hydrolase 3

Protein Summary

Description

Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin.

Uniprot Accession IDs

• Q9H6B9
• A3KMR3
• EH3

Gene Name

• EPHX3

Ensembl ID

• ENST00000221730
• ENSP00000221730
• ENSG00000105131
• ENST00000435261
• ENSP00000410323
• ENST00000602233
• ENSP00000469345

Symbol

• ABHD9
• EH3
• ABHD9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.67
PubMedID	0.6
tissue	0.52
transcription factor	0.52
chemical	0.44

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Epoxide Hydrolase 3

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Epoxide Hydrolase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.36   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 116   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.36   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0