Property Summary

NCBI Gene PubMed Count 18
Grant Count 16
R01 Count 13
Funding $1,174,360.22
PubMed Score 42.04
PubTator Score 12.57

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (21)

Gene RIF (10)

PMID Text
26391493 Results provide some support for the involvement of BICC1 and PCLO in late-life depressive disorders and preliminary evidence that these genetic variants may also influence brain structural volumes
25178406 findings identify a role for increased levels of BICC1 in the pathophysiology of depressive behavior
24789909 identify Bicc1 as a genetic determinant of osteoblastogenesis and BMD and suggest that it does so by regulating Pkd2 transcript levels
24789909 Polymorphisms in intron 2 of BICC1 are associated with its expression and bone mineral density (BMD)
22910460 The minor T-allele of BICC1 has a protective role against major depressive disorder and its known structural and functional brain changes.
21922595 The nonsense mutation identified in BICC1 and associated with cystic renal dysplasia results in a complete loss of Wnt inhibitory activity. The point mutation in the SAM domain results in a 22% loss of activity.
20516156 Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
16385451 Observational study of gene-disease association. (HuGE Navigator)
15465627 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MAAQGEPGYLAAQSDPGSNSERSTDSPVPGSEDDLVAGATLHSPEWSEERFRVDRKKLEAMLQAAAEGKG      1 - 70
RSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVS     71 - 140
HTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFE    141 - 210
LPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLA    211 - 280
SAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMG    281 - 350
CLPLVLMFDMKEEIEVDPQFIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESS    351 - 420
GVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSS    421 - 490
GTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQ    491 - 560
TEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGM    561 - 630
PRSPSHSGNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSER    631 - 700
AAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAE    701 - 770
TIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRK    771 - 840
QNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQ    841 - 910
DLKELGITTFGARRKMLLAISELNKNRRKLFESPNARTSFLEGGASGRLPRQYHSDIASVSGRW          911 - 974
//

Text Mined References (23)

PMID Year Title
26391493 2016 GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations.
25178406 2015 BICC1 expression is elevated in depressed subjects and contributes to depressive behavior in rodents.
24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
24789909 2014 Bicc1 is a genetic determinant of osteoblastogenesis and bone mineral density.
24501278 2014 Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation.
23396134 2013 Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.
23322567 2013 Identification of a candidate gene for astigmatism.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22910460 2012 Effect of genetic variant in BICC1 on functional and structural brain changes in depression.
More...