Tchem SUV39H2 Histone-lysine N-methyltransferase SUV39H2

Protein Summary

Description

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation.

Uniprot Accession IDs

• Q9H5I1
• D3DRT4
• Q5JSS4
• Q5JSS5
• Q6I9Y3
• Q8ND06

Gene Name

• SUV39H2

Ensembl ID

• ENST00000313519
• ENSP00000319208
• ENSG00000152455
• ENST00000354919
• ENSP00000346997
• ENST00000378325
• ENSP00000367576

Symbol

• KMT1B
• KMT1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
histone modification site profile	0.89
gene perturbation	0.86
transcription factor perturbation	0.84

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.21   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 352   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.21   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 352   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 458

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0