Property Summary

NCBI Gene PubMed Count 32
PubMed Score 138.51
PubTator Score 26.71

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Myocardial Ischemia 169
Disease Target Count P-value
non-small cell lung cancer 2798 3.27259345453625E-40
lung carcinoma 2844 7.29684846733753E-25
breast carcinoma 1614 4.37978344333585E-15
Breast cancer 3099 5.17090271240088E-12
malignant mesothelioma 3163 1.94666090597354E-9
group 4 medulloblastoma 1875 3.8300194302048E-9
lung adenocarcinoma 2714 5.65945713984639E-8
ulcerative colitis 2087 1.91374769325015E-7
atypical teratoid/rhabdoid tumor 1095 2.97373525360598E-7
ovarian cancer 8492 1.00904603339569E-6
lung cancer 4473 1.18546646847204E-6
medulloblastoma, large-cell 6234 2.2838064208582E-6
adult high grade glioma 2148 5.16858487851869E-5
invasive ductal carcinoma 2950 6.99525596864288E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 3.78410804894394E-4
interstitial cystitis 2299 5.20537274424526E-4
Down syndrome 548 0.00282083731451393
ductal carcinoma in situ 1745 0.00298306250948238
Common variable immunodeficiency 98 0.00389730055892777
tuberculosis 1563 0.00425740990382567
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00575006986440536
primitive neuroectodermal tumor 3031 0.00944935923669238
Atopic dermatitis 944 0.00961360016356113
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.010190485376721
urothelial carcinoma 318 0.0131006275058504
cystic fibrosis 1670 0.0179878062285736
chronic lymphocytic leukemia 244 0.030705592905318
Waldenstrons macroglobulinemia 765 0.0351344026531479
Disease Target Count Z-score Confidence
Cancer 2346 4.199 2.1



Accession Q9H4X1 Q6NZ48 Q9UL69
Symbols RGC32


  Ortholog (12)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

Gene RIF (19)

25655049 Data suggest that expression of RGC32 is down-regulated in placental trophoblasts in women with pre-eclampsia as compared to women with normal term pregnancies; silencing RGC32 expression by RNA interference inhibits trophoblast migration/invasion.
25418473 RGC-32 expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.
25230890 In conclusion, the present study indicates that C5a may promote the proliferation of breast cancer cells through Akt1 activation of the RGC-32 gene.
24973210 results demonstrate for the first time that RGC-32 is a novel membrane regulator for macrophage phagocytosis.
24833469 Suggest that RGC32 is involved in tumorigenesis of human lung cancer, inducing apoptosis and inhibiting cell growth, migration, and invasion.
23715780 RGC32 promotes cell migration and invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-kappaB signaling pathway.
23000427 data suggest RGC-32 plays a dual role in multiple sclerosis, both as a regulator of T-cells mediated apoptosis and as a promoter of TGF-beta-mediated profibrotic effects in astrocytes
22163048 analysis of upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells, due to transcriptional activation by high levels of the differentially expressed RUNX1c transcription factor
21307346 Data demonstrate that RGC-32 interacts with Smad3 to mediate the epithelial-mesenchymal transition of human renal proximal tubular cells.
20862745 methylation-associated down-regulation of RGC32 plays an important role in the pathogenesis of NSCLC, particularly in females

AA Sequence


Text Mined References (34)

PMID Year Title
25655049 2015 Expression of RGC32 in human normal and preeclamptic placentas and its role in trophoblast cell invasion and migration.
25418473 2015 Response gene to complement 32 (RGC-32) expression on M2-polarized and tumor-associated macrophages is M-CSF-dependent and enhanced by tumor-derived IL-4.
25230890 2014 C5a stimulates the proliferation of breast cancer cells via Akt-dependent RGC-32 gene activation.
24973210 2014 Response gene to complement 32 protein promotes macrophage phagocytosis via activation of protein kinase C pathway.
24833469 2014 Knockdown of response gene to complement 32 (RGC32) induces apoptosis and inhibits cell growth, migration, and invasion in human lung cancer cells.
24068962 2013 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.
23715780 2013 Overexpression of response gene to complement 32 (RGC32) promotes cell invasion and induces epithelial-mesenchymal transition in lung cancer cells via the NF-?B signaling pathway.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23000427 2013 Dual role of Response gene to complement-32 in multiple sclerosis.
22163048 2011 Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells.