Tdark RAD21L1 Double-strand-break repair protein rad21-like protein 1

Protein Summary

Description

Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity).

Uniprot Accession IDs

• Q9H4I0
• B2RXL0
• B7ZBB1
• B7ZW76
• Q5W0X5

Gene Name

• RAD21L1

Ensembl ID

• ENST00000402452
• ENSP00000385925
• ENSG00000244588
• ENST00000409241
• ENSP00000386414

Symbol

• RAD21L
• RAD21L
• dJ545L17.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
histone modification site profile	0.68
tissue sample	0.51
biological process	0.46
phenotype	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.79   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 10   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.79   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0