Property Summary

NCBI Gene PubMed Count 21
PubMed Score 453.31
PubTator Score 55.59

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count
Cardiomyopathies 90
Colonic Neoplasms 126
Disease Target Count P-value
breast carcinoma 1614 6.68657058539858E-39
non-small cell lung cancer 2798 6.81668795999407E-24
Breast cancer 3099 9.98253117078201E-21
lung adenocarcinoma 2714 3.74185070802997E-15
lung carcinoma 2844 3.53121885521286E-11
pilocytic astrocytoma 3086 3.13811668461266E-6
cystic fibrosis 1670 4.65278658555859E-6
medulloblastoma, large-cell 6234 4.98694259802824E-6
posterior fossa group B ependymoma 1530 6.69276670919957E-6
intraductal papillary-mucinous carcinoma (IPMC) 2988 8.16918278127843E-5
intraductal papillary-mucinous adenoma (IPMA) 2956 1.3368414494506E-4
osteosarcoma 7933 1.61832267438433E-4
glioblastoma 5572 3.16000328997615E-4
pediatric high grade glioma 2712 6.98360654181687E-4
invasive ductal carcinoma 2950 7.59703108381011E-4
ulcerative colitis 2087 0.00118348299431465
pituitary cancer 1972 0.00217563521549916
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00259382567167809
aldosterone-producing adenoma 664 0.00971760535811948
ductal carcinoma in situ 1745 0.0122310458814236



Accession Q9H4E5 Q96KC1
Symbols TCL


  Ortholog (12)

Gene RIF (10)

26299518 FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site.
24928894 RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.
24434213 These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.
23253891 These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1.
23029280 Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility.
22971344 we identified RhoJ and its effector PAK1, as key modulators of melanoma cell sensitivity to DNA damage
21628409 Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation
21148427 RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
12960428 TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes

AA Sequence

CSII                                                                      211 - 214

Text Mined References (21)

PMID Year Title
26299518 2015 The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin.
25416956 2014 A proteome-scale map of the human interactome network.
24928894 2014 RhoJ interacts with the GIT-PIX complex and regulates focal adhesion disassembly.
24434213 2014 Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
23253891 2013 RhoJ modulates melanoma invasion by altering actin cytoskeletal dynamics.
23029280 2012 Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.
22971344 2012 RhoJ regulates melanoma chemoresistance by suppressing pathways that sense DNA damage.
22103495 2011 The role of RhoJ in endothelial cell biology and angiogenesis.
21628409 2011 RhoJ is an endothelial cell-restricted Rho GTPase that mediates vascular morphogenesis and is regulated by the transcription factor ERG.