Tchem SRMS Tyrosine-protein kinase Srms

Protein Summary

Description

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907).

Uniprot Accession IDs

• Q9H3Y6

Gene Name

• SRMS

Ensembl ID

• ENST00000217188
• ENSP00000217188
• ENSG00000125508

Symbol

• C20orf148
• SRM
• PTK70
• C20orf148
• dJ697K14.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.94
tissue	0.66
cell type or tissue	0.63
PubMedID	0.56

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Src Family / Tyrosine-protein Kinase Srms

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.94   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1