Tbio ADAMTS10 A disintegrin and metalloproteinase with thrombospondin motifs 10

Protein Summary

Description

Metalloprotease that participate in microfibrils assembly. Microfibrils are extracellular matrix components occurring independently or along with elastin in the formation of elastic tissues. This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H324
• M0QZE4
• ADAM-TS 10

Gene Name

• ADAMTS10

Ensembl ID

• ENST00000595838
• ENSP00000470501
• ENSG00000142303

Symbol

• WMS
• WMS1
• ADAM-TS10
• ADAMTS-10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
tissue sample	0.62
histone modification site profile	0.55
cell type or tissue	0.53
interacting protein	0.53

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10

Protein / Enzyme Modulator / Protease Inhibitor / Serine Protease Inhibitor / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / A Disintegrin And Metalloproteinase With Thrombospondin Motifs 10

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 148   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.77   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0