Tdark VCX2 Variable charge X-linked protein 2

Protein Summary

Description

May mediate a process in spermatogenesis or may play a role in sex ratio distortion. This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes that are expressed exclusively in male germ cells. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. This gene contains two copies of a 30 nt tandem repeat. Deletion of a nearby member of this family was implicated in cognitive disability. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q9H322
• A3KPB6
• Q4V9T2
• Q9P0H5

Gene Name

• VCX2

Ensembl ID

• ENST00000317103
• ENSP00000321309
• ENSG00000177504

Symbol

• VCX2R
• VCXB
• VCXB
• VCX2R
• VCX-2r

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.52
virus perturbation	0.45
disease	0.43
cell type or tissue	0.41
small molecule perturbation	0.4

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 4   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.59   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 4   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0