Tbio ZNF106 Zinc finger protein 106

Protein Summary

Description

RNA-binding protein. Specifically binds to 5'-GGGGCC-3' sequence repeats in RNA. Essential for maintenance of peripheral motor neuron and skeletal muscle function. Required for normal expression and/or alternative splicing of a number of genes in spinal cord and skeletal muscle, including the neurite outgrowth inhibitor RTN4. Also contributes to normal mitochondrial respiratory function in motor neurons, via an unknown mechanism.

Uniprot Accession IDs

• Q9H2Y7
• B4DZ40
• E9PE29
• Q6NSD9
• Q6PEK1
• Q86T43
• Q86T45
• Q86T50
• Q86T58
• Q86TA9
• Q96M37
• Q9H7B8
• Zfp-106

Gene Name

• ZNF106

Ensembl ID

• ENST00000263805
• ENSP00000263805
• ENSG00000103994
• ENST00000565380
• ENSP00000455674

Symbol

• SH3BP3
• ZFP106
• ZNF474
• SH3BP3
• ZFP106
• ZNF474

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.96
protein domain	0.85
microRNA	0.68
transcription factor	0.68
histone modification site profile	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.53   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.53   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0