PPA2
Inorganic pyrophosphatase 2, mitochondrial
Protein Summary
Hydrolyzes inorganic pyrophosphate (PubMed:27523597). This activity is essential for correct regulation of mitochondrial membrane potential, and mitochondrial organization and function (PubMed:27523598). The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
- ENST00000341695
- ENSP00000343885
- ENSG00000138777
- ENST00000348706
- ENSP00000313061
- ENST00000354147
- ENSP00000340352
- ENST00000432483
- ENSP00000389957
- SCFI
- SCFAI
- HSPC124
- SID6-306
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.9 | ||
disease perturbation | 0.87 | ||
transcription factor perturbation | 0.84 | ||
interacting protein | 0.83 | ||
virus perturbation | 0.79 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.44 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 94 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 115.44 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 94 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0