You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ADNP
Activity-dependent neuroprotector homeobox protein

Protein Summary
Description
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Vasoactive intestinal peptide is a neuroprotective factor that has a stimulatory effect on the growth of some tumor cells and an inhibitory effect on others. This gene encodes a protein that is upregulated by vasoactive intestinal peptide and may be involved in its stimulatory effect on certain tumor cells. The encoded protein contains one homeobox and nine zinc finger domains, suggesting that it functions as a transcription factor. This gene is also upregulated in normal proliferative tissues. Finally, the encoded protein may increase the viability of certain cell types through modulation of p53 activity. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000349014
  • ENSP00000342905
  • ENSG00000101126
  • ENST00000371602
  • ENSP00000360662
  • ENST00000396029
  • ENSP00000379346
  • ENST00000396032
  • ENSP00000379349
  • ENST00000621696
  • ENSP00000483881

Symbol
  • ADNP1
  • KIAA0784
  • ADNP1
  • HVDAS
  • MRD28
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor binding site profile
0.94
histone modification site profile
0.72
PubMedID
0.72
transcription factor
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.81   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 319   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 181.81   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 319   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0