| Tchem | Serine/threonine-protein kinase TAO3 |
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 1.3e-07 |
| ovarian cancer | 8520 | 4.4e-05 |
| medulloblastoma | 720 | 1.5e-04 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.1e-04 |
| Waldenstrons macroglobulinemia | 765 | 1.5e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 3.7e-03 |
| lung cancer | 4740 | 4.4e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 6.2e-03 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 8.5e-03 |
| ulcerative colitis | 1819 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypertrophic cardiomyopathy 9 | 1 | 4.156 | 2.1 |
| Epilepsy | 792 | 3.869 | 1.9 |
| Koolen de Vries syndrome | 18 | 3.584 | 1.8 |
| Charcot-Marie-Tooth disease axonal type 2L | 5 | 3.45 | 1.7 |
| Acute dacryocystitis | 2 | 3.069 | 1.5 |
| Cyclothymic disorder | 8 | 3.048 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | -1.700 | 3.7e-03 |
| intraductal papillary-mucinous adenoma (... | 1.700 | 6.1e-04 |
| intraductal papillary-mucinous carcinoma... | 1.300 | 6.2e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.700 | 8.5e-03 |
| lung cancer | -1.200 | 4.4e-03 |
| medulloblastoma | -1.200 | 1.5e-04 |
| medulloblastoma, large-cell | -2.700 | 1.3e-07 |
| ovarian cancer | -1.500 | 4.4e-05 |
| ulcerative colitis | -1.237 | 1.6e-02 |
| Waldenstrons macroglobulinemia | 1.099 | 1.5e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
![Structure of compound 89S [PMID: 19115845]](/idg/structure/56bb86dc-2d0b-4457-a6d2-b70d7a247b4a.svg)
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDIL 1 - 70 KEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHS 71 - 140 HALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGIT 141 - 210 CIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRD 211 - 280 RPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSI 281 - 350 PSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ 351 - 420 SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHR 421 - 490 LKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICK 491 - 560 EKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQN 561 - 630 IREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRK 631 - 700 HVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAE 701 - 770 QYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA 771 - 840 HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR 841 - 898 //
