Tchem | Serine/threonine-protein kinase TAO3 |
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]
Comments
Disease | Target Count | P-value |
---|---|---|
medulloblastoma, large-cell | 6234 | 1.30849812139517E-7 |
ovarian cancer | 8492 | 4.37132281381849E-5 |
lung cancer | 4473 | 9.40441585123229E-5 |
medulloblastoma | 1524 | 1.53958523052525E-4 |
intraductal papillary-mucinous adenoma (IPMA) | 2956 | 6.14350733673569E-4 |
Waldenstrons macroglobulinemia | 765 | 0.00152660770272228 |
atypical teratoid / rhabdoid tumor | 4369 | 0.00372476805688958 |
intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 0.00622487784353917 |
intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 0.00847539354068137 |
ulcerative colitis | 2087 | 0.0156898319253128 |
Disease | log2 FC | p |
---|---|---|
Waldenstrons macroglobulinemia | 1.099 | 0.002 |
atypical teratoid / rhabdoid tumor | -1.700 | 0.004 |
medulloblastoma | -1.200 | 0.000 |
medulloblastoma, large-cell | -2.700 | 0.000 |
ulcerative colitis | -1.237 | 0.016 |
intraductal papillary-mucinous adenoma (... | 1.700 | 0.001 |
intraductal papillary-mucinous carcinoma... | 1.300 | 0.006 |
intraductal papillary-mucinous neoplasm ... | 1.700 | 0.008 |
lung cancer | -1.700 | 0.000 |
ovarian cancer | -1.500 | 0.000 |
Species | Source |
---|---|
Macaque | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA EggNOG Inparanoid |
Dog | OMA EggNOG Inparanoid |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDIL 1 - 70 KEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHS 71 - 140 HALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGIT 141 - 210 CIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRD 211 - 280 RPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSI 281 - 350 PSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQ 351 - 420 SVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHR 421 - 490 LKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICK 491 - 560 EKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQN 561 - 630 IREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRK 631 - 700 HVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAE 701 - 770 QYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRA 771 - 840 HLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR 841 - 898 //
PMID | Year | Title |
---|---|---|
26646899 | 2015 | Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood. |
25857706 | 2015 | TAOK3 phosphorylates the methylenecyclopropane nucleoside MBX 2168 to its monophosphate. |
24909733 | 2014 | TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population. |
24275569 | 2014 | An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. |
23186163 | 2013 | Toward a comprehensive characterization of a human cancer cell phosphoproteome. |
21406692 | 2011 | System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. |
21269460 | 2011 | Initial characterization of the human central proteome. |
20949042 | 2010 | Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. |
20379614 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | |
20068231 | 2010 | Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. |
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