Tbio SLC38A1 Sodium-coupled neutral amino acid transporter 1

Protein Summary

Description

Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA. Amino acid transporters play essential roles in the uptake of nutrients, production of energy, chemical metabolism, detoxification, and neurotransmitter cycling. SLC38A1 is an important transporter of glutamine, an intermediate in the detoxification of ammonia and the production of urea. Glutamine serves as a precursor for the synaptic transmitter, glutamate (Gu et al., 2001 [PubMed 11325958]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H2H9
• Q8NC61
• Q8NCF8
• Q96JX2
• Q9H2Q2

Gene Name

• SLC38A1

Ensembl ID

• ENST00000398637
• ENSP00000381634
• ENSG00000111371
• ENST00000439706
• ENSP00000398142
• ENST00000546893
• ENSP00000447853
• ENST00000549049
• ENSP00000449607

Symbol

• ATA1
• NAT2
• SAT1
• SNAT1
• ATA1
• NAT2
• SAT1
• SNAT1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.9
microRNA	0.9
kinase perturbation	0.88
molecular function	0.88

Protein Classes

PANTHER Classes

Protein / Transporter / Amino Acid Transporter / Sodium-coupled Neutral Amino Acid Transporter 1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc38 Family Of Sodium-dependent Neutral Amino Acid Transporters / System A-like Transporters / Sodium-coupled Neutral Amino Acid Transporter 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.83   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.83   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0