Tbio TSPYL2 Testis-specific Y-encoded-like protein 2

Protein Summary

Description

Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• Q9H2G4
• O94799
• Q96DG7
• Q9BZW6
• TSPY-like protein 2

Gene Name

• TSPYL2

Ensembl ID

• ENST00000375442
• ENSP00000364591
• ENSG00000184205

Symbol

• CDA1
• DENTT
• TSPX
• CDA1
• CTCL
• NP79
• TSPX
• CINAP
• DENTT
• SE204
• HRIHFB2216

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
cellular component	0.75
transcription factor	0.67
small molecule perturbation	0.6
histone modification site profile	0.59

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Testis-specific Y-encoded-like Protein 2

Protein / Chaperone / Testis-specific Y-encoded-like Protein 2

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Testis-specific Y-encoded-like Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.48   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 225   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.48   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0