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Tchem
SLK
STE20-like serine/threonine-protein kinase

Protein Summary
Description
Mediates apoptosis and actin stress fiber dissolution.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335753
  • ENSP00000336824
  • ENSG00000065613
  • ENST00000369755
  • ENSP00000358770

Symbol
  • KIAA0204
  • STK2
  • LOSK
  • STK2
  • se20-9
  • bA16H23.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
small molecule
0.99
molecular function
0.98
transcription factor perturbation
0.94
protein domain
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.49   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 364.49   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3