Property Summary

NCBI Gene PubMed Count 29
PubMed Score 10.43
PubTator Score 100.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (5)

Disease Target Count P-value
oligodendroglioma 2849 8.64743136541279E-13
ependymoma 2514 3.36761656268117E-11
tuberculosis 1563 5.10162025477859E-8
pilocytic astrocytoma 3086 9.95164857091632E-7
primitive neuroectodermal tumor 3031 9.99913026661905E-7
breast carcinoma 1614 1.07310485542668E-6
ovarian cancer 8492 2.65627081163355E-6
malignant mesothelioma 3163 5.07973101147877E-6
psoriasis 6685 6.91193767593789E-6
pituitary cancer 1972 1.48518405114492E-5
osteosarcoma 7933 3.5796415068268E-5
group 3 medulloblastoma 2254 1.01526338752257E-4
atypical teratoid / rhabdoid tumor 4369 2.15949437448768E-4
adult high grade glioma 2148 5.04040607829987E-4
astrocytoma 1493 0.0032906047463297
subependymal giant cell astrocytoma 2287 0.00612485488266948
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00635783119316161
non primary Sjogren syndrome sicca 840 0.010060902832687
invasive ductal carcinoma 2950 0.0137155417585672
glioblastoma 5572 0.042091100171657
Disease Target Count Z-score Confidence
Carcinoma 2147 0.0 1.0
Disease Target Count Z-score Confidence
Nonsyndromic deafness 121 4.933 2.5
Disease Target Count
Deafness, Autosomal Recessive 28 1
Disease Target Count
Deafness, autosomal recessive, 28 1

Expression

  Differential Expression (20)

Disease log2 FC p
malignant mesothelioma -1.100 0.000
psoriasis 2.900 0.000
astrocytoma 1.600 0.003
glioblastoma 1.600 0.042
oligodendroglioma 1.100 0.000
osteosarcoma -2.575 0.000
ependymoma 1.400 0.000
atypical teratoid / rhabdoid tumor 1.400 0.000
primitive neuroectodermal tumor 1.400 0.000
tuberculosis 1.500 0.000
pancreatic ductal adenocarcinoma liver m... 1.525 0.006
breast carcinoma -1.300 0.000
adult high grade glioma 1.100 0.001
group 3 medulloblastoma 1.300 0.000
pilocytic astrocytoma 1.300 0.000
non primary Sjogren syndrome sicca 1.600 0.010
subependymal giant cell astrocytoma 2.289 0.006
invasive ductal carcinoma -1.121 0.014
ovarian cancer 2.200 0.000
pituitary cancer 1.800 0.000

Synonym

Accession Q9H2D6 B1AHD4 B1AHD7 F2Z2W0 F8W6V6 O94797 Q2PZW8 Q2Q3Z9 Q2Q400 Q5R3M6 Q96DW1 Q9BT77 Q9BTL7 Q9BY98 Q9Y3L4
Symbols TARA
TAP68
DFNB28
dJ37E16.4
HRIHFB2122

Gene

  Ortholog (8)

Pathway (1)

Gene RIF (10)

PMID Text
25333879 TRIOBP-1 aggregates are implicated for the first time as a biological element of the neuropathology of a subset of chronic mental illness
25130170 High TRIOBP expression is associated with pancreatic cancer.
24692559 TAP68 functions in mediating TRF1-tankyrase 1 localization to the centrosome and in mitotic regulation
22820163 the centrosomal localization of Tara depended on the Thr-457 phosphorylation and the kinase activity of Plk1.
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19996280 Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
19913121 Observational study of gene-disease association. (HuGE Navigator)
18194665 All these findings suggest that HECTD3 may facilitate cell cycle progression via regulating ubiquitination and degradation of Tara.
16385458 Mutations in a novel isoform of TRIOBP that encodes a filamentous-actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss.
16385457 Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness.

AA Sequence

MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSG      1 - 70
CQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDS     71 - 140
ATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKED    141 - 210
TGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASS    211 - 280
PHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQ    281 - 350
LDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSP    351 - 420
NRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRAS    421 - 490
SPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPR    491 - 560
ASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQ    561 - 630
RDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSC    631 - 700
AQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRT    701 - 770
SCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTK    771 - 840
RDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFP    841 - 910
LRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSS    911 - 980
HNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESE    981 - 1050
PPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAP   1051 - 1120
RASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQD   1121 - 1190
PPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGE   1191 - 1260
TRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEG   1261 - 1330
RSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSA   1331 - 1400
RTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAA   1401 - 1470
KAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWG   1471 - 1540
AEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALG   1541 - 1610
PELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAG   1611 - 1680
LEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSW   1681 - 1750
RMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLK   1751 - 1820
YYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTS   1821 - 1890
APDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRAR   1891 - 1960
TPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKW   1961 - 2030
QELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGH   2031 - 2100
IPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEEL   2101 - 2170
SRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQEL   2171 - 2240
LRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMM   2241 - 2310
QKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE                  2311 - 2365
//

Text Mined References (35)

PMID Year Title
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25333879 2014 Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia.
25130170 2015 The actin-bundling protein TRIOBP-4 and -5 promotes the motility of pancreatic cancer cells.
24692559 2014 The 68-kDa telomeric repeat binding factor 1 (TRF1)-associated protein (TAP68) interacts with and recruits TRF1 to the spindle pole during mitosis.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22820163 2012 Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
21406692 2011 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
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