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Tbio
CXCL16
C-X-C motif chemokine 16

Protein Summary
Description
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis (By similarity). Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293778
  • ENSP00000293778
  • ENSG00000161921
  • ENST00000574412
  • ENSP00000459592

Symbol
  • SCYB16
  • SRPSOX
  • SRPSOX
  • CXCLG16
  • SR-PSOX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.94
PubMedID
0.84
biological term
0.82
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.82   (req: < 5)
Gene RIFs: 177   (req: <= 3)
Antibodies: 445   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.82   (req: >= 5)
Gene RIFs: 177   (req: > 3)
Antibodies: 445   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0