Tbio DCSTAMP Dendritic cell-specific transmembrane protein

Protein Summary

Description

Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

Uniprot Accession IDs

• Q9H295
• B7ZVW2
• E7ESG0
• Q2M2D5
• DC-STAMP

Gene Name

• DCSTAMP

Ensembl ID

• ENST00000297581
• ENSP00000297581
• ENSG00000164935
• ENST00000517991
• ENSP00000428869
• ENST00000622554
• ENSP00000480546

Symbol

• TM7SF4
• FIND
• TM7SF4
• hDC-STAMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.83
biological process	0.64
cellular component	0.61
transcription factor	0.5
PubMedID	0.48

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.35   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 72   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.35   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0