Property Summary

NCBI Gene PubMed Count 171
PubMed Score 1370.84
PubTator Score 1218.96

Knowledge Summary

Patent (11,245)


  Disease Sources (6)

Disease Target Count P-value
Breast cancer 3099 7.27639961685027E-38
non-small cell lung cancer 2798 2.84559934807296E-15
glioblastoma multiforme 347 2.9426364046548E-9
medulloblastoma, large-cell 6234 9.31920907701497E-6
atypical teratoid / rhabdoid tumor 4369 2.47523165597225E-5
pituitary cancer 1972 3.51394188790873E-5
oligodendroglioma 2849 9.98729024566026E-5
head and neck cancer and chronic obstructive pulmonary disease 237 1.57007636748599E-4
hepatocellular carcinoma 550 4.60597301756305E-4
adrenocortical carcinoma 1427 4.97810913429326E-4
group 3 medulloblastoma 2254 5.89762156645888E-4
ductal carcinoma in situ 1745 0.00129780542815591
invasive ductal carcinoma 2950 0.00138980948552785
pancreatic cancer 2300 0.00263315727323183
pancreatic carcinoma 567 0.00263315727323183
primary Sjogren syndrome 789 0.00285170816868043
gastric cancer 436 0.00549825267727322
mucosa-associated lymphoid tissue lymphoma 480 0.0134041193204883
tuberculosis 1563 0.0160187200674061
primitive neuroectodermal tumor 3031 0.0191587441821454
pilocytic astrocytoma 3086 0.0310599618380744
sarcoidosis 368 0.0331598344982698
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0332183568205838
Disease Target Count
platelet-type bleeding disorder 8 3
Disease Target Count
Bleeding disorder, platelet-type 8 1



Accession Q9H244 D3DNJ5 Q546J7 P2Y12
Symbols HORK3


PANTHER Protein Class (2)


1T78   1VZ1   1Y9C   4NTJ   4PXZ   4PY0  

  Ortholog (9)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA EggNOG Inparanoid

  TechDev Info (1)

Gene RIF (169)

26885820 The ratio of ADP- to TRAP-induced platelet aggregation quantifies P2Y12-dependent platelet inhibition independently of the platelet count in contrast to conventional ADP-induced aggregation.
26870959 PON1, P2Y12 and COX1 polymorphisms were associated with poorer vascular outcomes in patients with extracranial or intracranial stents.
26743169 Synergistic inhibition of both P2Y1 and P2Y12 adenosine diphosphate receptors by GLS-409 immediately attenuates platelet-mediated thrombosis and effectively blocks agonist-stimulated platelet aggregation irrespective of concomitant aspirin therapy.
26391841 ADP stimulation of P2Y12 led to cAMP decrease that, in turn, caused changes in phospholipase C phosphorylation by protein kinase A, increase in cytoplasmic calcium level and, consequently, PS+ platelet formation
26354056 Report appropriate P2Y12 inhibitor regimen to prevent increased bleeding risk and maintain antiplatelet efficacy in East Asian patients with acute coronary syndrome. in Korean patients
26353776 While there is increasing evidence for the cancer-protective effect of aspirin, this study suggests P2Y12 inhibition may also play a role.
26311415 In non-ST elevation acute coronary syndrome patients undergoing PCI a loading dose of ticagrelor or prasugrel given during the procedure provides optimal P2Y12-ADP receptor blockade in 2 h and maximal inhibition within 4 h.
26083990 Baseline platelet aggregation was increased in carriers of the common alleles of P2Y12 SNPs rs1907637, rs2046934, and rs6809699 and rs6787801 TC heterozygotes.
25838093 Leukotriene E4 may play some important roles in allergic mucus secretion partially via activation of P2Y12 receptor
25778862 This is the first study to demonstrate that the genetic polymorphisms of P2RY12 can affect platelet and eosinophil activation in patients with aspirin-exacerbated respiratory disease after aspirin exposure.

AA Sequence


Text Mined References (171)

PMID Year Title
26885820 2016 The Ratio of ADP- to TRAP-Induced Platelet Aggregation Quantifies P2Y12-Dependent Platelet Inhibition Independently of the Platelet Count.
26870959 2016 Association of PON1, P2Y12 and COX1 with Recurrent Ischemic Events in Patients with Extracranial or Intracranial Stenting.
26743169 2016 Synergistic Inhibition of Both P2Y1 and P2Y12 Adenosine Diphosphate Receptors As Novel Approach to Rapidly Attenuate Platelet-Mediated Thrombosis.
26391841 2015 Modulation and pre-amplification of PAR1 signaling by ADP acting via the P2Y12 receptor during platelet subpopulation formation.
26354056 2015 A pharmacodynamic study of the optimal P2Y12 inhibitor regimen for East Asian patients with acute coronary syndrome.
26353776 2015 Aspirin and P2Y12 inhibition attenuate platelet-induced ovarian cancer cell invasion.
26311415 2015 Onset of optimal P2Y12-ADP receptor blockade after ticagrelor and prasugrel intake in Non-ST elevation acute coronary syndrome.
26083990 2015 Influence of P2Y12 polymorphisms on platelet activity but not ex-vivo antiplatelet effect of ticagrelor in healthy Chinese male subjects.
25838093 2015 Leukotriene E4 induces MUC5AC release from human airway epithelial NCI-H292 cells.
25778862 2015 Association of P2RY12 polymorphisms with eosinophil and platelet activation in patients with aspirin-exacerbated respiratory disease.