Tclin S1PR5 Sphingosine 1-phosphate receptor 5

Protein Summary

Description

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9H228
• Q6NW11
• S1P receptor 5

Gene Name

• S1PR5

Ensembl ID

• ENST00000333430
• ENSP00000328472
• ENSG00000180739
• ENST00000439028
• ENSP00000416915

Symbol

• EDG8
• EDG8
• S1P5
• Edg-8
• SPPR-1
• SPPR-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.7
histone modification site profile	0.59
protein domain	0.58
tissue sample	0.58
gene perturbation	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Sphingosine 1-phosphate Receptor 5

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Sphingosine 1-phosphate Receptor 5

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.49   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 365   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.49   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 256

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4