Tchem MYLK2 Myosin light chain kinase 2, skeletal/cardiac muscle

Protein Summary

Description

Implicated in the level of global muscle contraction and cardiac function. Phosphorylates a specific serine in the N-terminus of a myosin light chain. This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9H1R3
• Q569L1
• Q96I84
• MLCK2

Gene Name

• MYLK2

Ensembl ID

• ENST00000375985
• ENSP00000365152
• ENSG00000101306
• ENST00000375994
• ENSP00000365162

Symbol

• KMLC
• MLCK
• MLCK2
• skMLCK

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
protein domain	0.85
hub protein	0.75
interacting protein	0.72
cell type or tissue	0.69

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Mlck Family / Myosin Light Chain Kinase 2, Skeletal/cardiac Muscle

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 134   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 129.25   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0